Cytotoxicity study of the interleukin-12-expressing recombinant Newcastle disease virus strain, rAF-IL12, towards CT26 colon cancer cells in vitro and in vivo

Cytotoxicity study of the interleukin-12-expressing recombinant Newcastle disease virus strain, rAF-IL12, towards CT26 colon cancer cells in vitro and in vivo

Abstract Background Oncolytic viruses have emerged as an alternative therapeutic modality for cancer as they can replicate specifically in tumour cells and induce toxic effects leading to apoptosis. Despite the great potentials and promising results shown in multiple studies, it appears that their e...

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Bibliographic Details
Main Authors: Syed Umar Faruq Syed Najmuddin, Zahiah Mohamed Amin, Sheau Wei Tan, Swee Keong Yeap, Jeevanathan Kalyanasundram, Muhamad Alhapis Che Ani, Abhimanyu Veerakumarasivam, Soon Choy Chan, Suet Lin Chia, Khatijah Yusoff, Noorjahan Banu Alitheen
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Cancer Cell International
Subjects:
Colon cancer
Recombinant NDV
Apoptosis
Immune systems
Online Access:http://link.springer.com/article/10.1186/s12935-020-01372-y

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http://link.springer.com/article/10.1186/s12935-020-01372-y

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