Metabolomics Discovers Early-Response Metabolic Biomarkers that Can Predict Chronic Reproductive Fitness in Individual Daphnia magna
Chemical risk assessment remains entrenched in chronic toxicity tests that set safety thresholds based on animal pathology or fitness. Chronic tests are resource expensive and lack mechanistic insight. Discovering a chemical’s mode-of-action can in principle provide predictive molecular bi...
Main Authors: | Nadine S. Taylor, Alex Gavin, Mark R. Viant |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2018-07-01
|
Series: | Metabolites |
Subjects: | |
Online Access: | http://www.mdpi.com/2218-1989/8/3/42 |
Similar Items
-
Defining the Baseline and Oxidant Perturbed Lipidomic Profiles of Daphnia magna
by: Nadine S. Taylor, et al.
Published: (2017-03-01) -
ERGO: Breaking Down the Wall between Human Health and Environmental Testing of Endocrine Disrupters
by: Henrik Holbech, et al.
Published: (2020-04-01) -
Identification of non-validated endocrine disrupting chemical characterization methods by screening of the literature using artificial intelligence and by database exploration
by: Elias Zgheib, et al.
Published: (2021-09-01) -
Direct Infusion Based Metabolomics Identifies Metabolic Disease in Patients’ Dried Blood Spots and Plasma
by: Hanneke A. Haijes, et al.
Published: (2019-01-01) -
Early microRNA indicators of PPARα pathway activation in the liver
by: Brian N. Chorley, et al.
Published: (2020-01-01)