Metabolomics Discovers Early-Response Metabolic Biomarkers that Can Predict Chronic Reproductive Fitness in Individual Daphnia magna

Metabolomics Discovers Early-Response Metabolic Biomarkers that Can Predict Chronic Reproductive Fitness in Individual Daphnia magna

Chemical risk assessment remains entrenched in chronic toxicity tests that set safety thresholds based on animal pathology or fitness. Chronic tests are resource expensive and lack mechanistic insight. Discovering a chemical’s mode-of-action can in principle provide predictive molecular bi...

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Bibliographic Details
Main Authors: Nadine S. Taylor, Alex Gavin, Mark R. Viant
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:Metabolites
Subjects:
DIMS
direct infusion mass spectrometry
omics
toxicogenomics
OECD test guideline
AOP
key event
adverse outcome
MoA
PLS regression
Online Access:http://www.mdpi.com/2218-1989/8/3/42

Internet

http://www.mdpi.com/2218-1989/8/3/42

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