In-Depth Comparison of Lysine-Based Antibody-Drug Conjugates Prepared on Solid Support Versus in Solution

In-Depth Comparison of Lysine-Based Antibody-Drug Conjugates Prepared on Solid Support Versus in Solution

Antibody drug conjugates are a rapidly growing form of targeted chemotherapeutics. As companies and researchers move to develop new antibody–drug conjugate (ADC) candidates, high-throughput methods will become increasingly common. Here we use advanced characterization techniques to assess two trastu...

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Bibliographic Details
Main Authors: Keith J. Arlotta, Aditya V. Gandhi, Hsiao-Nung Chen, Christine S. Nervig, John F. Carpenter, Shawn C. Owen
Format: Article
Language:English
Published: MDPI AG 2018-01-01
Series:Antibodies
Subjects:
antibody drug conjugates
protein A
LC/MS
Raman
DSC
DLS
ITC
trastuzumab
DM1
one-step
Online Access:http://www.mdpi.com/2073-4468/7/1/6

Internet

http://www.mdpi.com/2073-4468/7/1/6

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