Treatment of SEC62 over-expressing tumors by Thapsigargin and Trifluoperazine

Treatment of SEC62 over-expressing tumors by Thapsigargin and Trifluoperazine

Treatment with analogues of the SERCA-inhibitor Thapsigargin is a promising new approach for a wide variety of cancer entities. However, our previous studies on various tumor cells suggested resistance of SEC62 over-expressing tumors to this treatment. Therefore, we proposed the novel concept that e...

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Bibliographic Details
Main Authors: Körbel Christina, Linxweiler Maximilian, Bochen Florian, Wemmert Silke, Schick Bernhard, Meyer Markus, Maurer Hans, Menger Michael D, Zimmermann Richard, Greiner Markus
Format: Article
Language:English
Published: De Gruyter 2018-05-01
Series:Biomolecular Concepts
Subjects:
calmodulin antagonists
endoplasmic reticulum
sec62 protein
trifluoperazine
tumor therapy
Online Access:https://doi.org/10.1515/bmc-2018-0006

Internet

https://doi.org/10.1515/bmc-2018-0006

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