STAT3 imparts BRCAness by impairing homologous recombination repair in Epstein-Barr virus-transformed B lymphocytes.

STAT3 imparts BRCAness by impairing homologous recombination repair in Epstein-Barr virus-transformed B lymphocytes.

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Epstein-Barr virus (EBV) causes lymphomas and epithelial cell cancers. Though generally silent in B lymphocytes, this widely prevalent virus can cause endemic Burkitt lymphoma and post-transplant lymphoproliferative disorders/lymphomas in immunocompromised hosts. By learning how EBV breaches barrier...

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Bibliographic Details
Main Authors: Michael T McIntosh, Siva Koganti, J Lucas Boatwright, Xiaofan Li, Salvatore V Spadaro, Alexis C Brantly, Jasmine B Ayers, Ramon D Perez, Eric M Burton, Sandeepta Burgula, Thomas MacCarthy, Sumita Bhaduri-McIntosh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-10-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1008849

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https://doi.org/10.1371/journal.ppat.1008849

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