CBP/p300 Bromodomain Inhibitor–I–CBP112 Declines Transcription of the Key ABC Transporters and Sensitizes Cancer Cells to Chemotherapy Drugs

CBP/p300 Bromodomain Inhibitor–I–CBP112 Declines Transcription of the Key ABC Transporters and Sensitizes Cancer Cells to Chemotherapy Drugs

The high expression of some ATP-binding cassette (ABC) transporters is linked to multidrug resistance in cancer cells. We aimed to determine if I-CBP112, which is a CBP/p300 bromodomain inhibitor, altered the vulnerability of the MDA-MB-231 cell line to chemotherapy drugs, which are used in neoadjuv...

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Bibliographic Details
Main Authors: Magdalena Strachowska, Karolina Gronkowska, Sylwia Michlewska, Agnieszka Robaszkiewicz
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Cancers
Subjects:
I-CBP112
CBP/p300 bromodomain inhibitor
ATP-binding cassette transporters (ABC)
lysine-specific demethylase 1A (LSD1)
histone modifications
anticancer drugs
Online Access:https://www.mdpi.com/2072-6694/13/18/4614

Internet

https://www.mdpi.com/2072-6694/13/18/4614

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