In the absence of effector proteins, the Pseudomonas aeruginosa type three secretion system needle tip complex contributes to lung injury and systemic inflammatory responses.

In the absence of effector proteins, the Pseudomonas aeruginosa type three secretion system needle tip complex contributes to lung injury and systemic inflammatory responses.

Herein we describe a pathogenic role for the Pseudomonas aeruginosa type three secretion system (T3SS) needle tip complex protein, PcrV, in causing lung endothelial injury. We first established a model in which P. aeruginosa wild type strain PA103 caused pneumonia-induced sepsis and distal organ dys...

Full description

Bibliographic Details
Main Authors: Jonathon P Audia, Ashley S Lindsey, Nicole A Housley, Courtney R Ochoa, Chun Zhou, Michie Toba, Masahiko Oka, Naga S Annamdevula, Meshann S Fitzgerald, Dara W Frank, Diego F Alvarez
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3842252?pdf=render

Internet

http://europepmc.org/articles/PMC3842252?pdf=render

Similar Items