Adenosine A2a Receptor Stimulation Attenuates Ischemia-Reperfusion Injury and Improves Survival in A Porcine Model of DCD Liver Transplantation

Adenosine A2a Receptor Stimulation Attenuates Ischemia-Reperfusion Injury and Improves Survival in A Porcine Model of DCD Liver Transplantation

Orthotopic liver transplantation (OLT) using allografts from donation after circulatory death (DCD) is potentially associated with compromised clinical outcomes due to ischemia-reperfusion injury (IRI)-induced organ damage and graft-related complications. The aim of this study was to provide in vivo...

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Bibliographic Details
Main Authors: Zoltan Czigany, Eve Christiana Craigie, Georg Lurje, Shaowei Song, Kei Yonezawa, Yuzo Yamamoto, Thomas Minor, René Hany Tolba
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
adenosine A2a agonist
liver transplantation
microcirculation
porcine model
donation after circulatory death
survival
Online Access:https://www.mdpi.com/1422-0067/21/18/6747

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https://www.mdpi.com/1422-0067/21/18/6747

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