Pharmacokinetic modelling for the simultaneous assessment of perfusion and 18F-flutemetamol uptake in cerebral amyloid angiopathy using a reduced PET-MR acquisition time: Proof of concept

Pharmacokinetic modelling for the simultaneous assessment of perfusion and 18F-flutemetamol uptake in cerebral amyloid angiopathy using a reduced PET-MR acquisition time: Proof of concept

Purpose: Cerebral amyloid angiopathy (CAA) is a cerebral small vessel disease associated with perivascular β-amyloid deposition. CAA is also associated with strokes due to lobar intracerebral haemorrhage (ICH). 18F-flutemetamol amyloid ligand PET may improve the early detection of CAA. We performed...

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Bibliographic Details
Main Authors: Giorgos Papanastasiou, Mark A. Rodrigues, Chengjia Wang, Kerstin Heurling, Christophe Lucatelli, Rustam Al-Shahi Salman, Joanna M. Wardlaw, Edwin J.R. van Beek, Gerard Thompson
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:NeuroImage
Subjects:
Positron emission tomography
Magnetic resonance imaging
Pharmacokinetic modelling
Perfusion
18F-flutemetamol uptake
Cerebral amyloid angiopathy
Online Access:http://www.sciencedirect.com/science/article/pii/S1053811920309678

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http://www.sciencedirect.com/science/article/pii/S1053811920309678

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