20-HETE and EETs in diabetic nephropathy: a novel mechanistic pathway.

Diabetic nephropathy (DN), a major complication of diabetes, is characterized by hypertrophy, extracellular matrix accumulation, fibrosis and proteinuria leading to loss of renal function. Hypertrophy is a major factor inducing proximal tubular epithelial cells injury. However, the mechanisms leadin...

Full description

Bibliographic Details
Main Authors: Stephanie Eid, Rita Maalouf, Ayad A Jaffa, Joseph Nassif, Ahmed Hamdy, Awad Rashid, Fuad N Ziyadeh, Assaad A Eid
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3732284?pdf=render