PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-α and-γ via IRF1 inductionResearch in context

PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-α and-γ via IRF1 inductionResearch in context

Background: Antibodies targeting PD-1 and its ligand PDL1 are used in cancer immunotherapy but may lead to autoimmune diseases, including type 1 diabetes (T1D). It remains unclear whether PDL1 is expressed in pancreatic islets of people with T1D and how is it regulated. Methods: The expression of PD...

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Bibliographic Details
Main Authors: Maikel L. Colli, Jessica L.E. Hill, Laura Marroquí, Jessica Chaffey, Reinaldo S. Dos Santos, Pia Leete, Alexandra Coomans de Brachène, Flavia M.M. Paula, Anne Op de Beeck, Angela Castela, Lorella Marselli, Lars Krogvold, Knut Dahl-Jorgensen, Piero Marchetti, Noel G. Morgan, Sarah J. Richardson, Décio L. Eizirik
Format: Article
Language:English
Published: Elsevier 2018-10-01
Series:EBioMedicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396418303980

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http://www.sciencedirect.com/science/article/pii/S2352396418303980

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