Maintenance of Genomic Stability in Mouse Embryonic Stem Cells: Relevance in Aging and Disease

Maintenance of Genomic Stability in Mouse Embryonic Stem Cells: Relevance in Aging and Disease

Recent studies have shown that mouse embryonic stem cells (mESCs) rely on a distinctive genome caretaking network. In this review, we will discuss how mESCs functionally respond to DNA damage and describe several modifications in mESC DNA damage response, which accommodate dynamic cycling and preser...

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Bibliographic Details
Main Authors: Valentina Turinetto, Claudia Giachino, Luca Orlando
Format: Article
Language:English
Published: MDPI AG 2013-01-01
Series:International Journal of Molecular Sciences
Subjects:
embryonic stem cells
genotoxic stress
DNA repair
aging
tumor
Online Access:http://www.mdpi.com/1422-0067/14/2/2617
Description
Summary:Recent studies have shown that mouse embryonic stem cells (mESCs) rely on a distinctive genome caretaking network. In this review, we will discuss how mESCs functionally respond to DNA damage and describe several modifications in mESC DNA damage response, which accommodate dynamic cycling and preservation of genetic information. Subsequently, we will discuss how the transition from mESCs to adult stem/progenitor cells can be involved in the decline of tissue integrity and function in the elderly.
ISSN:1422-0067

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