The hydrophobic nature of a novel membrane interface regulates the enzyme activity of a voltage-sensing phosphatase

The hydrophobic nature of a novel membrane interface regulates the enzyme activity of a voltage-sensing phosphatase

Voltage-sensing phosphatases (VSP) contain a voltage sensor domain (VSD) similar to that of voltage-gated ion channels but lack a pore-gate domain. A VSD in a VSP regulates the cytoplasmic catalytic region (CCR). However, the mechanisms by which the VSD couples to the CCR remain elusive. Here we rep...

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Bibliographic Details
Main Authors: Akira Kawanabe, Masaki Hashimoto, Manami Nishizawa, Kazuhisa Nishizawa, Hirotaka Narita, Tomoko Yonezawa, Yuka Jinno, Souhei Sakata, Atsushi Nakagawa, Yasushi Okamura
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-11-01
Series:eLife
Subjects:
voltage sensor
ascidian
phosphoinositide
phosphatase
membrane interaction
domain to domain coupling
Online Access:https://elifesciences.org/articles/41653

Internet

https://elifesciences.org/articles/41653

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