Relationships between mitochondrial function and metabolic flexibility in type 2 diabetes mellitus.

INTRODUCTION: Mitochondrial dysfunction, lipid accumulation, insulin resistance and metabolic inflexibility have been implicated in the etiology of type 2 diabetes (T2D), yet their interrelationship remains speculative. We investigated these interrelationships in a group of T2D and obese normoglycem...

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Main Authors: Tineke van de Weijer, Lauren Marie Sparks, Esther Phielix, Ruth Carla Meex, Noud Antonius van Herpen, Matthijs Karel C Hesselink, Patrick Schrauwen, Vera Bettina Schrauwen-Hinderling
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3572106?pdf=render