Crystal Structure of a Retroviral Polyprotein: Prototype Foamy Virus Protease-Reverse Transcriptase (PR-RT)

Crystal Structure of a Retroviral Polyprotein: Prototype Foamy Virus Protease-Reverse Transcriptase (PR-RT)

In most cases, proteolytic processing of the retroviral Pol portion of the Gag-Pol polyprotein precursor produces protease (PR), reverse transcriptase (RT), and integrase (IN). However, foamy viruses (FVs) express Pol separately from Gag and, when Pol is processed, only the IN domain is released. He...

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Bibliographic Details
Main Authors: Jerry Joe E. K. Harrison, Steve Tuske, Kalyan Das, Francesc X. Ruiz, Joseph D. Bauman, Paul L. Boyer, Jeffrey J. DeStefano, Stephen H. Hughes, Eddy Arnold
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Viruses
Subjects:
PFV
Pol polyprotein
PR-RT
protease
reverse transcriptase
maturation
Online Access:https://www.mdpi.com/1999-4915/13/8/1495

Internet

https://www.mdpi.com/1999-4915/13/8/1495

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