Notch pathway: a bistable inducer of biological noise?

Abstract Notch signalling pathway is central to development of metazoans. The pathway codes a binary fate switch. Upon activation, downstream signals contribute to resolution of fate dichotomies such as proliferation/differentiation or sub-lineage differentiation outcome. There is, however, an inter...

Full description

Bibliographic Details
Main Authors: Filip Vujovic, Neil Hunter, Ramin M. Farahani
Format: Article
Language:English
Published: BMC 2019-10-01
Series:Cell Communication and Signaling
Online Access:http://link.springer.com/article/10.1186/s12964-019-0453-0