Pharmacological ablation of the airway smooth muscle layer—Mathematical predictions of functional improvement in asthma

Abstract Airway smooth muscle (ASM) plays a major role in acute airway narrowing and reducing ASM thickness is expected to attenuate airway hyper‐responsiveness and disease burden. There are two therapeutic approaches to reduce ASM thickness: (a) a direct approach, targeting specific airways, best e...

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Bibliographic Details
Main Authors: Graham M. Donovan, Kimberley C. W. Wang, Danial Shamsuddin, Tracy S. Mann, Peter J. Henry, Alexander N. Larcombe, Peter B. Noble
Format: Article
Language:English
Published: Wiley 2020-06-01
Series:Physiological Reports
Subjects:
Online Access:https://doi.org/10.14814/phy2.14451