Repeated infusion of mesenchymal stem cells maintain the condition to inhibit deteriorated motor function, leading to an extended lifespan in the SOD1G93A rat model of amyotrophic lateral sclerosis

Repeated infusion of mesenchymal stem cells maintain the condition to inhibit deteriorated motor function, leading to an extended lifespan in the SOD1G93A rat model of amyotrophic lateral sclerosis

Abstract Amyotrophic lateral sclerosis (ALS) is a neurodegenerative fatal disorder in which motor neurons within the brain and spinal cord degenerate. A single infusion of mesenchymal stem cells (MSCs) delays disease progression by protecting motor neurons and restoring the blood-spinal cord barrier...

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Bibliographic Details
Main Authors: Hirotoshi Magota, Masanori Sasaki, Yuko Kataoka-Sasaki, Shinichi Oka, Ryo Ukai, Ryo Kiyose, Rie Onodera, Jeffery D. Kocsis, Osamu Honmou
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Molecular Brain
Subjects:
Amyotrophic lateral sclerosis
Mesenchymal stem cells intravenous
Multiple doses
Quality of life
Online Access:https://doi.org/10.1186/s13041-021-00787-6

Internet

https://doi.org/10.1186/s13041-021-00787-6

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