Influenza A virus hemagglutinin mutations associated with use of neuraminidase inhibitors correlate with decreased inhibition by anti-influenza antibodies

Influenza A virus hemagglutinin mutations associated with use of neuraminidase inhibitors correlate with decreased inhibition by anti-influenza antibodies

Abstract Background Vaccination and the use of neuraminidase inhibitors (NAIs) are currently the front lines of defense against seasonal influenza. The activity of influenza vaccines and antivirals drugs such as the NAIs can be affected by mutations in the influenza hemagglutinin (HA) protein. Numer...

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Bibliographic Details
Main Authors: Natalia A. Ilyushina, Takashi E. Komatsu, William L. Ince, Eric F. Donaldson, Nicolette Lee, Julian J. O’Rear, Raymond P. Donnelly
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Virology Journal
Subjects:
Hemagglutinin (HA)
Neuraminidase (NA)
Neuraminidase inhibitors (NAI)
Influenza A virus
Antiviral resistance
Online Access:https://doi.org/10.1186/s12985-019-1258-x

Internet

https://doi.org/10.1186/s12985-019-1258-x

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