Intermittent Transcription Dynamics for the Rapid Production of Long Transcripts of High Fidelity

Normal cellular function relies on the efficient and accurate readout of the genetic code. Single-molecule experiments show that transcription and replication are highly intermittent processes that are frequently interrupted by polymerases pausing and reversing directions. Although intermittent dyn...

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Bibliographic Details
Main Authors: Martin Depken, Juan M.R. Parrondo, Stephan W. Grill
Format: Article
Language:English
Published: Elsevier 2013-10-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124713005159