Slowing disease progression in the SOD1 mouse model of ALS by blocking neuregulin-induced microglial activation

Slowing disease progression in the SOD1 mouse model of ALS by blocking neuregulin-induced microglial activation

There are no effective treatments to slow disease progression in ALS. We previously reported that neuregulin (NRG) receptors are constitutively activated on microglia in the ventral horns in both ALS patients and SOD1 mice and in the corticospinal tracts of ALS patients, and that NRG receptor activa...

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Bibliographic Details
Main Authors: Jianguo Liu, Elise Allender, Jiajing Wang, Eleanor H. Simpson, Jeffrey A. Loeb, Fei Song
Format: Article
Language:English
Published: Elsevier 2018-03-01
Series:Neurobiology of Disease
Subjects:
Neuregulin
Neuregulin antagonist HBD-S-H4
Microglial activation
Motor neuron
Amyotrophic lateral sclerosis
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611730298X

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http://www.sciencedirect.com/science/article/pii/S096999611730298X

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