ROCK-phosphorylated vimentin modifies mutant huntingtin aggregation via sequestration of IRBIT

ROCK-phosphorylated vimentin modifies mutant huntingtin aggregation via sequestration of IRBIT

<p>Abstract</p> <p>Background</p> <p>Huntington's Disease (HD) is a fatal hereditary neurodegenerative disease caused by the accumulation of mutant huntingtin protein (Htt) containing an expanded polyglutamine (polyQ) tract. Activation of the channel responsible fo...

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Bibliographic Details
Main Authors: Bauer Peter O, Hudec Roman, Goswami Anand, Kurosawa Masaru, Matsumoto Gen, Mikoshiba Katsuhiko, Nukina Nobuyuki
Format: Article
Language:English
Published: BMC 2012-08-01
Series:Molecular Neurodegeneration
Subjects:
Vimentin
IP3R1
IRBIT
Rho-kinase
Huntingtin
Aggregation
Online Access:http://www.molecularneurodegeneration.com/content/7/1/43

Internet

http://www.molecularneurodegeneration.com/content/7/1/43

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