Loss of Adhesion in the Circulation Converts Amelanotic Metastatic Melanoma Cells to Melanotic by Inhibition of AKT

Loss of Adhesion in the Circulation Converts Amelanotic Metastatic Melanoma Cells to Melanotic by Inhibition of AKT

Direct injection of murine K-1735 melanoma cells into the subcutis, lung, or brain of syngeneic mice produces amelanotic tumors, whereas intravenous injection into the lateral tail vein or internal carotid artery produces both amelanotic and melanotic foci in the lung and the brain respectively. We...

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Bibliographic Details
Main Authors: Weihua Zhang, Rachel Tsan, Do-Hyun Nam, Weixin Lu, Isaiah J. Fidler
Format: Article
Language:English
Published: Elsevier 2006-07-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Adhesion
circulation
melanoma
organ microenvironment
AKT
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558606800096

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http://www.sciencedirect.com/science/article/pii/S1476558606800096

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