Regioselective alkynylation followed by Suzuki coupling of 2,4-dichloroquinoline: Synthesis of 2-alkynyl-4-arylquinolines

Regioselective alkynylation followed by Suzuki coupling of 2,4-dichloroquinoline: Synthesis of 2-alkynyl-4-arylquinolines

A two step synthesis of 2-alkynyl-4-arylquinolines has been accomplished via Pd/C-mediated regioselective C-2 alkynylation of 2,4-dichloroquinoline in water followed by Suzuki coupling at C-4 of the resulting 4-chloro derivative.

Bibliographic Details
Main Authors: Ellanki A. Reddy, Aminul Islam, K. Mukkanti, Venkanna Bandameedi, Dipal R. Bhowmik, Manojit Pal
Format: Article
Language:English
Published: Beilstein-Institut 2009-07-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
alkyne
boronic acid
catalysis
2,4-dichloroquinoline
palladium
water
Online Access:https://doi.org/10.3762/bjoc.5.32

Internet

https://doi.org/10.3762/bjoc.5.32

Similar Items