NEUROD1 Instructs Neuronal Conversion in Non-Reactive Astrocytes

NEUROD1 Instructs Neuronal Conversion in Non-Reactive Astrocytes

Currently, all methods for converting non-neuronal cells into neurons involve injury to the brain; however, whether neuronal transdifferentiation can occur long after the period of insult remains largely unknown. Here, we use the transcription factor NEUROD1, previously shown to convert reactive gli...

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Bibliographic Details
Main Authors: Rebecca Brulet, Taito Matsuda, Ling Zhang, Carlos Miranda, Mauro Giacca, Brian K. Kaspar, Kinichi Nakashima, Jenny Hsieh
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:Stem Cell Reports
Subjects:
NeuroD
transdifferentiation
reprogramming
neurons
astrocytes
cortex
striatum
AAV9
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671117301674

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http://www.sciencedirect.com/science/article/pii/S2213671117301674

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