DLBCL with amplification of JAK2/PD-L2 exhibits PMBCL-like CNA pattern and worse clinical outcome resembling those with MYD88 L265P mutation

DLBCL with amplification of JAK2/PD-L2 exhibits PMBCL-like CNA pattern and worse clinical outcome resembling those with MYD88 L265P mutation

Abstract Background Recently, copy number alteration (CNA) of 9p24.1 were demonstrated in 10% of diffuse large b-cell lymphoma (DLBCL), with gene expression and mutation profiles that were similar to those of primary mediastinal large B-cell lymphoma (PMBCL). However, their CNA-based profile and cli...

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Bibliographic Details
Main Authors: Xuemin Xue, Wenting Huang, Tian Qiu, Lei Guo, Jianming Ying, Ning Lv
Format: Article
Language:English
Published: BMC 2020-08-01
Series:BMC Cancer
Subjects:
Diffuse large B-cell lymphoma
JAK2
PD-L2
Amplification
Prognosis
Online Access:http://link.springer.com/article/10.1186/s12885-020-07293-3

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http://link.springer.com/article/10.1186/s12885-020-07293-3

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