FAK Deficiency in Bone Marrow Stromal Cells Alters Their Homeostasis and Drives Abnormal Proliferation and Differentiation of Haematopoietic Stem Cells

FAK Deficiency in Bone Marrow Stromal Cells Alters Their Homeostasis and Drives Abnormal Proliferation and Differentiation of Haematopoietic Stem Cells

Emerging evidence indicates that in myelodysplastic syndromes (MDS), the bone marrow (BM) microenvironment may also contribute to the ineffective, malignant haematopoiesis in addition to the intrinsic abnormalities of haematopoietic stem precursor cells (HSPCs). The BM microenvironment influences ma...

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Bibliographic Details
Main Authors: Yuenv Wu, Lydia Campos, Elisabeth Daguenet, Zhiguo He, Tiphanie Picot, Emmanuelle Tavernier-Tardy, Gilbert Soglu, Denis Guyotat, Carmen-Mariana Aanei
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Cells
Subjects:
bone marrow stromal cells (bmscs)
focal adhesion kinase (fak)
myelodysplastic syndromes (mds)
haematopoietic stem precursor cell (hspc)–bmsc interaction
adhesion molecules
lymphocyte function-associated antigen 1 (lfa-1)
cd44
Online Access:https://www.mdpi.com/2073-4409/9/3/646

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https://www.mdpi.com/2073-4409/9/3/646

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