High Interferon-γ Uniquely in Vδ1 T Cells Correlates with Markers of Inflammation and Axonal Damage in Early Multiple Sclerosis

High Interferon-γ Uniquely in Vδ1 T Cells Correlates with Markers of Inflammation and Axonal Damage in Early Multiple Sclerosis

We have identified a population of T lymphocytes in peripheral blood, Vδ1 TCRγδ T lymphocytes, which unexpectedly was uniquely expressing high production of interferon-γ in newly diagnosed, untreated multiple sclerosis (MS) patients. IFN-γ production in this population distinctly correlated to param...

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Bibliographic Details
Main Authors: Avadhesh Kumar Singh, Lenka Novakova, Markus Axelsson, Clas Malmeström, Henrik Zetterberg, Jan Lycke, Susanna L. Cardell
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-03-01
Series:Frontiers in Immunology
Subjects:
cerebrospinal fluid
gamma-delta T cells
interferon-gamma
multiple sclerosis
natalizumab
Vdelta1 T cells
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00260/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00260/full

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