Brain-Derived Neurotrophic Factor Mitigates the Association Between Platelet Dysfunction and Cognitive Impairment

Brain-Derived Neurotrophic Factor Mitigates the Association Between Platelet Dysfunction and Cognitive Impairment

Background: Platelet hyperactivity is deleterious in coronary artery disease (CAD), requiring lifelong antiplatelet therapy, and is associated with worse cognitive outcomes. Upon activation, platelets release Brain-Derived Neurotrophic Factor (BDNF), a neurotrophin protective against cognitive decli...

Full description

Bibliographic Details
Main Authors: Jean-Christophe Bélanger, Véronique Bouchard, Jessica Le Blanc, Louisia Starnino, Mélanie Welman, Malorie Chabot-Blanchet, David Busseuil, Howard Chertkow, Bianca D'Antono, Marie Lordkipanidzé
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
platelets
BDNF
coronary artery disease
cognitive impairment
mediation model
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.739045/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2021.739045/full

Similar Items