‘<i>All That Glitters Is Not Gold</i>’: High-Resolution Crystal Structures of Ligand-Protein Complexes Need Not Always Represent Confident Binding Poses

‘<i>All That Glitters Is Not Gold</i>’: High-Resolution Crystal Structures of Ligand-Protein Complexes Need Not Always Represent Confident Binding Poses

Our understanding of the structure–function relationships of biomolecules and thereby applying it to drug discovery programs are substantially dependent on the availability of the structural information of ligand–protein complexes. However, the correct interpretation of the electron density of a sma...

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Bibliographic Details
Main Authors: Sohini Chakraborti, Kaushik Hatti, Narayanaswamy Srinivasan
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
quality assessment
ligand–protein crystal structures
resolution
electron density map
binding pose
PDB
Online Access:https://www.mdpi.com/1422-0067/22/13/6830

Internet

https://www.mdpi.com/1422-0067/22/13/6830

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