An interplay between UCP2 and ROS protects cells from high-salt-induced injury through autophagy stimulation

An interplay between UCP2 and ROS protects cells from high-salt-induced injury through autophagy stimulation

Abstract The mitochondrial uncoupling protein 2 (UCP2) plays a protective function in the vascular disease of both animal models and humans. UCP2 downregulation upon high-salt feeding favors vascular dysfunction in knock-out mice, and accelerates cerebrovascular and renal damage in the stroke-prone...

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Main Authors: Maurizio Forte, Franca Bianchi, Maria Cotugno, Simona Marchitti, Rosita Stanzione, Vittorio Maglione, Sebastiano Sciarretta, Valentina Valenti, Roberto Carnevale, Francesco Versaci, Giacomo Frati, Massimo Volpe, Speranza Rubattu
Format: Article
Language:English
Published: Nature Publishing Group 2021-10-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-04188-4

Internet

https://doi.org/10.1038/s41419-021-04188-4

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