Patient‐specific logic models of signaling pathways from screenings on cancer biopsies to prioritize personalized combination therapies

Patient‐specific logic models of signaling pathways from screenings on cancer biopsies to prioritize personalized combination therapies

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Abstract Mechanistic modeling of signaling pathways mediating patient‐specific response to therapy can help to unveil resistance mechanisms and improve therapeutic strategies. Yet, creating such models for patients, in particular for solid malignancies, is challenging. A major hurdle to build these...

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Bibliographic Details
Main Authors: Federica Eduati, Patricia Jaaks, Jessica Wappler, Thorsten Cramer, Christoph A Merten, Mathew J Garnett, Julio Saez‐Rodriguez
Format: Article
Language:English
Published: Wiley 2020-02-01
Series:Molecular Systems Biology
Subjects:
drug combinations
logic modeling
patient‐specific models
precision oncology
signaling pathways
Online Access:https://doi.org/10.15252/msb.20188664

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