Dual Activity BLEG-1 from <i>Bacillus lehensis</i> G1 Revealed Structural Resemblance to B3 Metallo-β-Lactamase and Glyoxalase II: An Insight into Its Enzyme Promiscuity and Evolutionary Divergence

Dual Activity BLEG-1 from <i>Bacillus lehensis</i> G1 Revealed Structural Resemblance to B3 Metallo-β-Lactamase and Glyoxalase II: An Insight into Its Enzyme Promiscuity and Evolutionary Divergence

Metallo-β-lactamases (MBLs) are class B β-lactamases from the metallo-hydrolase-like MBL-fold superfamily which act on a broad range of β-lactam antibiotics. A previous study on BLEG-1 (formerly called Bleg1_2437), a hypothetical protein from <i>Bacillus lehensis</i> G1, revealed sequenc...

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Bibliographic Details
Main Authors: Shaw Xian Au, Nur Syazana Dzulkifly, Noor Dina Muhd Noor, Hiroyoshi Matsumura, Raja Noor Zaliha Raja Abdul Rahman, Yahaya M. Normi
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
BLEG-1
metallo-β-lactamase
glyoxalase II
enzyme promiscuity
evolutionary divergence
crystal structure
Online Access:https://www.mdpi.com/1422-0067/22/17/9377

Internet

https://www.mdpi.com/1422-0067/22/17/9377

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