Protein-Mediated and RNA-Based Origins of Replication of Extrachromosomal Mycobacterial Prophages

Bacteriophages are the most abundant biological entities in the biosphere and are a source of uncharacterized biological mechanisms and genetic tools. Here, we identify segments of phage genomes that are used for stable extrachromosomal replication in the prophage state. Autonomous replication of so...

Full description

Bibliographic Details
Main Authors: Katherine S. Wetzel, Haley G. Aull, Kira M. Zack, Rebecca A. Garlena, Graham F. Hatfull
Format: Article
Language:English
Published: American Society for Microbiology 2020-03-01
Series:mBio
Subjects:
Online Access:https://doi.org/10.1128/mBio.00385-20