Dysregulated APOBEC3G causes DNA damage and promotes genomic instability in multiple myeloma
Abstract Multiple myeloma (MM) is a heterogeneous disease characterized by significant genomic instability. Recently, a causal role for the AID/APOBEC deaminases in inducing somatic mutations in myeloma has been reported. We have identified APOBEC/AID as a prominent mutational signature at diagnosis...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2021-10-01
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| Series: | Blood Cancer Journal |
| Online Access: | https://doi.org/10.1038/s41408-021-00554-9 |