Developmental YAPdeltaC determines adult pathology in a model of spinocerebellar ataxia type 1

Developmental YAPdeltaC determines adult pathology in a model of spinocerebellar ataxia type 1

Ataxin-1, linked to spinocerebellar ataxia type 1, is known to interact with the orphan nuclear receptor RORα. Here, Fujita and colleagues show that genetic supplementation of RORα-interacting protein YAPdeltaC during early development can rescue the adult pathologies of SCA1 mouse model.

Bibliographic Details
Main Authors: Kyota Fujita, Ying Mao, Shigenori Uchida, Xigui Chen, Hiroki Shiwaku, Takuya Tamura, Hikaru Ito, Kei Watase, Hidenori Homma, Kazuhiko Tagawa, Marius Sudol, Hitoshi Okazawa
Format: Article
Language:English
Published: Nature Publishing Group 2017-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01790-z

Internet

https://doi.org/10.1038/s41467-017-01790-z

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