EAE in beta-2 microglobulin-deficient mice: axonal damage is not dependent on MHC-I restricted immune responses

EAE in beta-2 microglobulin-deficient mice: axonal damage is not dependent on MHC-I restricted immune responses

There is accumulating evidence that CD8-positive (CD8+) T-cells and MHC-I expression may also play a role in neurodegeneration associated with multiple sclerosis (MS). We investigated the role of MHC-I and CD8+ T-cells by studying experimental autoimmune encephalomyelitis (EAE) in beta-2 microglobul...

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Bibliographic Details
Main Authors: Ralf A. Linker, Evelyn Rott, H.H. Hofstetter, T. Hanke, Klaus V. Toyka, Ralf Gold
Format: Article
Language:English
Published: Elsevier 2005-06-01
Series:Neurobiology of Disease
Subjects:
Axonal damage
Knockout mouse
Macrophage
Multiple sclerosis
T-cell
MOG-EAE
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996105000033

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http://www.sciencedirect.com/science/article/pii/S0969996105000033

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