Whole blood transcriptomics in cardiac surgery identifies a gene regulatory network connecting ischemia reperfusion with systemic inflammation.

Whole blood transcriptomics in cardiac surgery identifies a gene regulatory network connecting ischemia reperfusion with systemic inflammation.

Cardiac surgery with cardiopulmonary bypass (CS/CPB) is associated with increased risk for postoperative complications causing substantial morbidity and mortality. To identify the molecular mechanisms underlying CS/CPB-induced pathophysiology we employed an integrative systems biology approach using...

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Bibliographic Details
Main Authors: Orfeas Liangos, Sophie Domhan, Christian Schwager, Martin Zeier, Peter E Huber, Francesco Addabbo, Michael S Goligorsky, Lynn Hlatky, Bertrand L Jaber, Amir Abdollahi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-10-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2965092?pdf=render

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http://europepmc.org/articles/PMC2965092?pdf=render

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