A survey of the kinome pharmacopeia reveals multiple scaffolds and targets for the development of novel anthelmintics

Abstract Over one billion people are currently infected with a parasitic nematode. Symptoms can include anemia, malnutrition, developmental delay, and in severe cases, death. Resistance is emerging to the anthelmintics currently used to treat nematode infection, prompting the need to develop new ant...

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Bibliographic Details
Main Authors: Jessica Knox, Nicolas Joly, Edmond M. Linossi, José A. Carmona-Negrón, Natalia Jura, Lionel Pintard, William Zuercher, Peter J. Roy
Format: Article
Language:English
Published: Nature Publishing Group 2021-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-88150-6