Burkholderia Lethal Factor 1, a Novel Anti-Cancer Toxin, Demonstrates Selective Cytotoxicity in MYCN-Amplified Neuroblastoma Cells

Burkholderia Lethal Factor 1, a Novel Anti-Cancer Toxin, Demonstrates Selective Cytotoxicity in MYCN-Amplified Neuroblastoma Cells

Immunotoxins are being investigated as anti-cancer therapies and consist of a cytotoxic enzyme fused to a cancer targeting antibody. All currently used toxins function via the inhibition of protein synthesis, making them highly potent in both healthy and transformed cells. This non-specific cell kil...

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Bibliographic Details
Main Authors: Aleksander Rust, Sajid Shah, Guillaume M. Hautbergue, Bazbek Davletov
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:Toxins
Subjects:
ribosome-inactivating protein
BLF1
eIF4A
MYCN
cancer
neuroblastoma
apoptosis
Online Access:http://www.mdpi.com/2072-6651/10/7/261

Internet

http://www.mdpi.com/2072-6651/10/7/261

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