LKB1 deficiency-induced metabolic reprogramming in tumorigenesis and non-neoplastic diseases

LKB1 deficiency-induced metabolic reprogramming in tumorigenesis and non-neoplastic diseases

Background: Live kinase B1 (LKB1) is a tumor suppressor that is mutated in Peutz-Jeghers syndrome (PJS) and a variety of cancers. Lkb1 encodes serine-threonine kinase (STK) 11 that activates AMP-activated protein kinase (AMPK) and its 13 superfamily members, regulating multiple biological processes,...

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Bibliographic Details
Main Authors: Yanghe Zhang, Qingfei Meng, Qianhui Sun, Zhi-Xiang Xu, Honglan Zhou, Yishu Wang
Format: Article
Language:English
Published: Elsevier 2021-02-01
Series:Molecular Metabolism
Subjects:
Metabolism
LKB1
Tumorigenesis
Lipid
Immune cell
Glucose
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877820302052

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http://www.sciencedirect.com/science/article/pii/S2212877820302052

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