Immune mechanisms responsible for vaccination against and clearance of mucosal and lymphatic norovirus infection.

Two cardinal manifestations of viral immunity are efficient clearance of acute infection and the capacity to vaccinate against secondary viral exposure. For noroviruses, the contributions of T cells to viral clearance and vaccination have not been elucidated. We report here that both CD4 and CD8 T c...

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Bibliographic Details
Main Authors: Karen A Chachu, Anna D LoBue, David W Strong, Ralph S Baric, Herbert W Virgin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-12-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2587711?pdf=render