In vitro formation of β cell pseudoislets using islet-derived endothelial cells.

β cell pseudoislets (PIs) are used for the in vitro study of β-cells in a three-dimensional (3-D) configuration. Current methods of PI induction require unique culture conditions and extensive mechanical manipulations. Here we report a novel co-culture system consisting of high passage β-cells and i...

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Bibliographic Details
Main Authors: Michael G Spelios, Lauren A Kenna, Bonnie Wall, Eitan M Akirav
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3756083?pdf=render