Validation of genome-wide intervertebral disc calcification associations in Dachshund and further investigation of the chromosome 12 susceptibility locus

Validation of genome-wide intervertebral disc calcification associations in Dachshund and further investigation of the chromosome 12 susceptibility locus

Herniation of the intervertebral disc is a common cause of neurological dysfunction in the dog, particularly in the Dachshund. Using the Illumina CanineHD BeadChip, we have previously identified a major locus on canine chromosome 12 nucleotide positions 36,750,205-38,524,449 that strongly associates...

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Bibliographic Details
Main Authors: Mette Sloth eMogensen, Karsten eScheibye-Alsing, Peter eKarlskov-Mortensen, Helle Friis Proschowsky, Vibeke Frøkjær Jensen, Mads eBak, Niels eTommerup, Haja N Kadarmideen, Merete eFredholm
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-11-01
Series:Frontiers in Genetics
Subjects:
Resequencing
canine
intervertebral disc calcification
LD pattern
haplotype effects
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00225/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00225/full

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