The Chloride Homeostasis of CA3 Hippocampal Neurons Is Not Altered in Fully Symptomatic Mepc2-null Mice

The Chloride Homeostasis of CA3 Hippocampal Neurons Is Not Altered in Fully Symptomatic Mepc2-null Mice

Rett syndrome (RTT) is an X-linked neurodevelopmental disorder caused mainly by mutations in the MECP2 gene. Mouse models of RTT show reduced expression of the cation-chloride cotransporter KCC2 and altered chloride homeostasis at presymptomatic stages. However, whether these alterations persist to...

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Bibliographic Details
Main Authors: Yasmine Belaïdouni, Diabe Diabira, Jinwei Zhang, Jean-Charles Graziano, Francesca Bader, Aurelie Montheil, Clément Menuet, Gary A. Wayman, Jean-Luc Gaiarsa
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Cellular Neuroscience
Subjects:
KCC2
NKCC1
Rett
GABA
hippocampus
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2021.724976/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2021.724976/full

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