Multimodal Microvascular Imaging Reveals that Selective Inhibition of Class I PI3K Is Sufficient to Induce an Antivascular Response

Multimodal Microvascular Imaging Reveals that Selective Inhibition of Class I PI3K Is Sufficient to Induce an Antivascular Response

The phosphatidylinositol 3-kinase (PI3K) pathway is a central mediator of vascular endothelial growth factor (VEGF)-driven angiogenesis. The discovery of small molecule inhibitors that selectively target PI3K or PI3K and mammalian target of rapamycin (mTOR) provides an opportunity to pharmacologica...

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Bibliographic Details
Main Authors: Deepak Sampath, Jason Oeh, Shelby K. Wyatt, Tim C. Cao, Hartmut Koeppen, Jeffrey Eastham-Anderson, Liliane Robillard, Calvin C.K. Ho, Jed Ross, Guanglei Zhuang, Hani Bou Reslan, Philip Vitorino, Kai H. Barck, Sharon E. Ungersma, Jean Michel Vernes, Maresa Caunt, Nick Van Bruggen, Weilan Ye, Ulka Vijapurkar, Yu-Ju Gloria Meng, Napoleone Ferrara, Lori S. Friedman, Richard A.D. Carano
Format: Article
Language:English
Published: Elsevier 2013-07-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558613800644

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http://www.sciencedirect.com/science/article/pii/S1476558613800644

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