A double-blind randomized phase I clinical trial targeting ALVAC-HIV vaccine to human dendritic cells.

A double-blind randomized phase I clinical trial targeting ALVAC-HIV vaccine to human dendritic cells.

We conducted a novel pilot study comparing different delivery routes of ALVAC-HIV (vCP205), a canarypox vaccine containing HIV gene inserts: env, gag and pol. We explored the concept that direct ex vivo targeting of human dendritic cells (DC) would enhance the immune response compared to either conv...

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Bibliographic Details
Main Authors: Michael A Eller, Bonnie M Slike, Josephine H Cox, Emil Lesho, Zhining Wang, Jeffrey R Currier, Janice M Darden, Victoria R Polonis, Maryanne T Vahey, Sheila Peel, Merlin L Robb, Nelson L Michael, Mary A Marovich
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3174939?pdf=render

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http://europepmc.org/articles/PMC3174939?pdf=render

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