Molecular mechanism for the dual alcohol modulation of Cys-loop receptors.

Molecular mechanism for the dual alcohol modulation of Cys-loop receptors.

Cys-loop receptors constitute a superfamily of pentameric ligand-gated ion channels (pLGICs), including receptors for acetylcholine, serotonin, glycine and γ-aminobutyric acid. Several bacterial homologues have been identified that are excellent models for understanding allosteric binding of alcohol...

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Bibliographic Details
Main Authors: Samuel Murail, Rebecca J Howard, Torben Broemstrup, Edward J Bertaccini, R Adron Harris, James R Trudell, Erik Lindahl
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC3464191?pdf=render

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http://europepmc.org/articles/PMC3464191?pdf=render

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