Imatinib and Dasatinib Provoke Mitochondrial Dysfunction Leading to Oxidative Stress in C2C12 Myotubes and Human RD Cells

Imatinib and Dasatinib Provoke Mitochondrial Dysfunction Leading to Oxidative Stress in C2C12 Myotubes and Human RD Cells

Tyrosine kinase inhibitors (TKIs) can cause skeletal muscle toxicity in patients, but the underlying mechanisms are mostly unclear. The goal of the current study was to better characterize the role of mitochondria in TKI-associated myotoxicity. We exposed C2C12 murine myoblasts and myotubes as well...

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Bibliographic Details
Main Authors: Jamal Bouitbir, Miljenko Valentin Panajatovic, Theo Frechard, Noëmi Johanna Roos, Stephan Krähenbühl
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Pharmacology
Subjects:
imatinib
dasatinib
myotoxicity
electron transport chain (ETC)
reactive oxygen species (ROS)
apoptosis
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.01106/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.01106/full

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